Cosmetic Claim Support

Cosmetic Claim Support Services

Scientific Validation for Confident Cosmetic Marketing

At Axela Biosciences, we provide industry-leading in vitro and ex vivo human skin models and analytical tools to support evidence-based cosmetic claims. Whether you’re developing skincare, anti-aging, pigmentation, or sensitive skin products, our advanced testing platforms help validate efficacy, safety, and performance—before clinical trials or market launch.

In Vitro & Ex Vivo Human Skin Models

Our models replicate the complexity of human skin, allowing precise evaluation of ingredient and formulation effects.

Available Models & Materials:

  • Human primary keratinocytes, fibroblasts, melanocytes, and immune cells
  • 2D & 3D co-culture systems mimicking skin structure
  • Human skin equivalents: EpiDerm™, EpiDermFT™, MelanoDerm™
  • NativeSkin® ex vivo skin explants (full-thickness biopsies maintained up to 7 days)
  • 3D psoriasis skin models
  • D-Squame® tape for non-invasive skin biomarker analysis

What We Can Support:

Barrier Function & Hydration
  • TEER (trans-epithelial electrical resistance) measurements
  • Lipid synthesis and skin differentiation marker expression (e.g., loricrin, filaggrin)
  • Moisturizing effect and protein biomarker analysis
  • Proteo-transcriptomic profiling via D-Squame® strips
Pigmentation & Brightening
  • Melanin quantification and tyrosinase inhibition assays
  • Microscopic/macroscopic darkening assessment
  • Expression of pigmentation markers
UV Protection & Photoaging
  • UVA/UVB exposure with H&E and IHC readouts
  • DNA damage analysis (p53 activation, phototoxicity markers)
  • Antioxidant assays: ROS, DPPH, hydrogen peroxide scavenging
Cosmetogenomic Profiling
  • Customized gene expression panels for:
  • Elasticity, firmness, detoxification
  • Anti-microbial properties
  • Energy metabolism, soothing/anti-inflammatory activity
  • Longevity and cellular health
Anti-Aging
  • Enzyme activity: elastase, collagenase, hyaluronidase, tyrosinase
  • Collagen/elastin quantification, MMP and TIMP profiling
  • Senescence assays: SASP biomarkers, beta-galactosidase, Ki67
  • Telomere length (RT-PCR) and oxidative damage markers
Anti-Inflammatory & Soothing Effects
  • Cytokine and chemokine secretion (e.g., IL-6, IL-8, TNF-α, MCP-1)
  • Immune cell infiltration profiling (mast cells, macrophages, T cells)
  • Luminex-based multiplex cytokine analysis
Wound Healing & Regeneration
  • Scratch assays with keratinocytes/fibroblasts using live-cell imaging
  • Growth factor and ECM remodeling gene expression
  • Transcriptional profiling: IL1A, COL1A1, TGFB1, NFKB1, etc.
Technologies & Assay Platforms
  • NanoString GeoMx™ spatial genomics/proteomics
  • NanoString nCounter™ transcriptomics (770+ gene panels)
  • Luminex multiplex immunoassays
  • Live-cell imaging, H&E & IHC staining
  • qPCR arrays, automatic western blot
  • Multicolor flow cytometry
  • Epidermal separation and 3D dermatoscopy