Discovery Biology & Pharmacology
We provide a comprehensive suite of in vitro and translational biology services to support every stage of drug discovery and development. From early target validation and mechanistic studies to advanced models such as PROTAC discovery, 3D in vitro systems, and safety testing, our team combines scientific expertise with cutting-edge platforms to deliver reliable, actionable results. Whether you are exploring novel therapeutic targets, evaluating candidate compounds, or optimizing biomarker strategies, Axela is your trusted partner in transforming ideas into impactful therapies.
In Vitro Discovery Biology
💠Cytotoxicity and proliferation assays (3D cell culture, cell cycle, mitosis test)
💠Angiogenesis assays (EC adhesion, tube formation, aortic ring explant, VEGFR signaling)
💠Epigenetics assays (acetyltransferase, DNA methyltransferase, HDAC, histone demethylase/methyltransferase, PARP, bromodomain screening)
💠Live cell imaging: adhesion, migration, chemotaxis, wound healing
💠Cell-free assays: kinase, phosphatase, and other enzymatic assays
💠Multiplex analysis of mRNA and proteins
💠Reporter gene assays
💠Western blot platforms: in-cell western (ICW), traditional WB, SDS-PAGE, 2-D gel
Translational Development
💠Biomarker validation and measurement (Simple Western)
💠Mechanism of action studies for novel drugs
💠Anti-aging compound screening
💠Companion diagnostic development
💠Drug combination screening for synergy
💠Analysis of post-translational protein modifications
💠Candidate validation (low-density gene arrays, RT-PCR)
PROTAC Discovery
💠Design, validation, and profiling of novel PROTACs
💠Ligand binding and E3 ligase specificity assays
💠Quantification of target degradation (DC50, Dmax)
💠Selectivity analysis across the proteome (RPPA, IHC, WB)
💠CRBN, VHL binding, and ternary complex assays
Multiplex Live Cell Imaging
💠Real-time monitoring of cell adhesion, migration, chemotaxis, and wound healing
3-D In Vitro Models
💠Anti-psoriatic drug screening
💠Cancer cell viability and invasion assays
💠3D tumor micro-tissue and spheroid assays
💠Anti-aging cosmetic ingredient screening
In vitro Toxicology/Safety Test
💠DNA damage and repair (comet, DNA fiber assay, oxidation, methylation)
💠Ames test (mutagenicity, 2–5 strains)
💠Micronucleus test (MNT)
💠Mitochondrial toxicity assays
💠Hematotoxicity (CFU assays for fibroblast or mesenchymal toxicity)
💠Cell-specific cytotoxicity
Contact us at info@axelabio.com to discuss your discovery biology project.